by Anneke_e | Jul 31, 2026 | Publication
This review by Geoffrey Brown (University of Birmingham) revisits the long-standing question of when hematopoietic stem cells (HSCs) become lineage-affiliated during hematopoiesis. The classical model posits that lineage commitment occurs late and proceeds stepwise,...
by Anneke_e | Jul 31, 2026 | Publication
The transcription factors STAT3, STAT5A, and STAT5B are essential regulators of hematopoiesis and immunity, yet their aberrant activation drives acute myeloid leukemia (AML) and natural killer/T-cell lymphoma (NKCL). Current therapeutic approaches largely target...
by Anneke_e | Jul 31, 2026 | Publication
Prostate cancer is the second most commonly diagnosed cancer in men, and IL6ST/STAT3 signaling has been implicated in the progression of several tumor types, yet its specific role in prostate cancer had remained poorly defined. Sternberg et al. addressed this by...
