Structural and Thermodynamic Discrimination between Agonists and Antagonists of Retinoic Acid Receptor γ and the Vitamin D Receptor – Zołek et al.

by Anneke_e | Oct 20, 2026 | Publication

Synthetic ligands can switch RARγ and the vitamin D receptor (VDR) on or off, but what separates an agonist from an antagonist is not fully understood. This study uses docking, molecular dynamics simulations and binding-energy calculations to compare nine RARγ ligands...

Investigating Tissue Image Quality: Carmen’s Research Visit at Bond University

by Anneke_e | Oct 13, 2026 | Uncategorized

In September, following her research secondment at La Trobe University in Melbourne, Carmen Colin Tenorio continued her research visit in Australia at Bond University on the Gold Coast, hosted by Jyotsna Batra and Rupert Ecker. The visit continued the collaborative...

From Tissue Preparation to Image Analysis: Carmen’s Research Visit at La Trobe University

by Anneke_e | Oct 13, 2026 | Uncategorized

From late July to 31 August 2026, Carmen Colin Tenorio undertook a research secondment at La Trobe University in Melbourne, Australia, working with Professor Brian Abbey and his team. The visit brought her into contact with the experimental side of her PhD project at...

Metabolic Interactions of Side-chain Extended and Unsaturated Vitamin D Analogs with Cytochrome P450 Enzymes – Zołek et al.

by Anneke_e | Oct 6, 2026 | Publication

The active form of vitamin D3 (1,25D3) has anticancer potential, but its clinical use is limited by calcemic side effects and rapid breakdown by cytochrome P450 enzymes. This study characterises new vitamin D analogs (PRI-1927, PRI-1937, and PRI-1938) with extended,...

Thyroid hormone receptor beta signaling is a targetable driver of prostate cancer growth – Fesiuk et al.

by Anneke_e | Oct 6, 2026 | Publication

Thyroid hormone signalling has been linked to prostate cancer, but the role of its main effector, thyroid hormone receptor β (TRβ), was unclear. This study conducted by Fesiuk et al. shows that the TRβ-selective antagonist NH-3 inhibits prostate cancer cell...