This project aims to develop a strategy for enabling the efficient delivery of selected RARγ antagonist and VDR agonists. This will be achieved through a systematic approach, beginning with the determination of relevant physicochemical properties of the molecules via preformulation studies. Afterwards, the impact of these properties on functional and biopharmaceutical characteristics such as solubility, dissolution, and permeability will be established. Anti-crystal engineering principles based on polymers and/or other excipients will be applied to create supersaturable drug delivery systems, ensuring maximum solubility and flux across the membrane. The mechanism of drug release and the degree of supersaturation will be determined in vitro, with the goal of identifying an optimum delivery system.
This research will unveil key preformulation principles for formulating the investigated compounds, ultimately leading to the development of commercial prototypes.