POU1F1 induces cancer stem cell-like traits in breast cancer cells by IL-6/JAK2/ STAT3 activation and enrichment of ALDH – Avila et al.

by Anneke_e | Jul 31, 2026 | Publication

POU1F1 is a transcription factor that can push breast cancer cells toward a cancer stem cell‑like state. When POU1F1 levels are high, the cells produce more IL‑6, which activates the JAK2/STAT3 signaling pathway. This pathway is known for supporting cell survival,...

Microplastics role in cell migration and distribution during cancer cell division – Brynzak-Schreiber et al.

by Anneke_e | Jul 31, 2026 | Publication

The gastrointestinal tract represents a primary route of daily human exposure to micro- and nanoplastics, yet their behavior within tumor cells remains poorly understood. Brynzak-Schreiber, Schögl et al. investigated the uptake, intracellular distribution, and...

Kupffer cell programming by maternal obesity triggers fatty liver disease – Huang et al.

by Anneke_e | Jul 31, 2026 | Publication

Kupffer cells (KCs), the liver’s yolk sac-derived resident macrophages, acquire tissue-specific functions early in embryogenesis and remain essential throughout life for liver metabolism and homeostasis. Huang, Balzer et al. show that maternal obesity in mice...

Cell Lineage Affiliation During Hematopoiesis – Geoffrey Brown

by Anneke_e | Jul 31, 2026 | Publication

This review by Geoffrey Brown (University of Birmingham) revisits the long-standing question of when hematopoietic stem cells (HSCs) become lineage-affiliated during hematopoiesis. The classical model posits that lineage commitment occurs late and proceeds stepwise,...

Dual specific STAT3/5 degraders effectively block acute myeloid leukemia and natural killer/T cell lymphoma – Pölöske et al.

by Anneke_e | Jul 31, 2026 | Publication

The transcription factors STAT3, STAT5A, and STAT5B are essential regulators of hematopoiesis and immunity, yet their aberrant activation drives acute myeloid leukemia (AML) and natural killer/T-cell lymphoma (NKCL). Current therapeutic approaches largely target...

Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment – Sternberg et al.

by Anneke_e | Jul 31, 2026 | Publication

Prostate cancer is the second most commonly diagnosed cancer in men, and IL6ST/STAT3 signaling has been implicated in the progression of several tumor types, yet its specific role in prostate cancer had remained poorly defined. Sternberg et al. addressed this by...