Achievements
Publications
Structural and Thermodynamic Discrimination between Agonists and Antagonists of Retinoic Acid Receptor γ and the Vitamin D Receptor – Zołek et al.
Synthetic ligands can switch RARγ and the vitamin D receptor (VDR) on or off, but what separates an agonist from an antagonist is not…
Metabolic Interactions of Side-chain Extended and Unsaturated Vitamin D Analogs with Cytochrome P450 Enzymes – Zołek et al.
The active form of vitamin D3 (1,25D3) has anticancer potential, but its clinical use is limited by calcemic side effects and rapid breakdown by…
Thyroid hormone receptor beta signaling is a targetable driver of prostate cancer growth – Fesiuk et al.
Thyroid hormone signalling has been linked to prostate cancer, but the role of its main effector, thyroid hormone receptor…
The Influences of RARγ on the Behavior of Normal and Cancer Stem Cells – Geoffrey Brown
Retinoic acid receptor γ (RARγ) is expressed mainly in stem and progenitor cells and helps control whether they maintain stemness or…
The Emerging Oncogenic Role of RARγ: From Stem Cell Regulation to a Potential Cancer Therapy – Geoffrey Brown
Retinoic acid receptor γ (RARγ) is selectively expressed by normal stem cells and is needed to maintain…
Targeting Androgen, Thyroid Hormone, and Vitamin A and D Receptors to Treat Prostate Cancer – Hantusch et al.
Androgen deprivation therapy is the core treatment for prostate cancer, but many patients progress…
Structure and the Anticancer Activity of Vitamin D Receptor Agonists – Powała et al.
Vitamin D is best known for its role in calcium homeostasis and bone health, but growing evidence indicates that its active form, calcitriol, also regulates cellular processes involved in…
Small Particles, Big Problems: Polystyrene nanoparticles induce DNA damage, oxidative stress, migration, and mitogenic pathways predominantly in non-malignant lung cells – Ernhofer et al.
In this study, Ernhofer et al. investigated the effects of polystyrene micro- and nanoplastics (PS-MNPs) on non-malignant and malignant lung cell models, as well…
Molecular Interactions of Selective Agonists and Antagonists with the Retinoic Acid Receptor γ – Powała et al.
The three retinoic acid receptors (RARα, β, and γ) have distinct roles, so retinoid-based therapies need isoform-selective…
POU1F1 induces cancer stem cell-like traits in breast cancer cells by IL-6/JAK2/ STAT3 activation and enrichment of ALDH – Avila et al.
POU1F1 is a transcription factor that can push breast cancer cells toward a cancer stem cell‑like state. When POU1F1 levels are high, the cells produce…
Awards
Next Stop: Australia – Carmen Receives ÖFG Travel Grant
Carmen has been awarded a EUR 1,500 travel grant from the Austrian Science Fund (ÖFG) under the International Communication…
Celebrating Excellence at ACCORD 2026
As part of the 3rd eRaDicate Training School, the DCs attended the ACCORD 2026 Conference in Warsaw, where they had the opportunity to present their research,…
Geoffrey Brown Recognized as Highly Ranked Scholar by ScholarGPS
eRaDicate consortium member Geoffrey Brown from University of Birmingham has been named a Highly Ranked Scholar™ by…
Presentations
From Training to Podium: Carmen’s Contributions to ECDP 2026
At the 22nd European Congress on Digital Pathology (ECDP 2026) in Graz, Carmen delivered an oral presentation in the Bias in AI…