Research Project 11

Importance of RARγ to the malignant potential of AML blasts

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The project of this Doctoral Candidate (DC2-UWr) will aim to determine the roles of retinoic acid receptors (RAR) α and γ in the development of acute myeloid leukemia (AML). This DC will investigate the relative expressions of RARA and RARG in bone marrow leukocytes from healthy people and in blasts from patients with preleukemic states and with leukemias. DC will also study miRNAs in AML cell lines with overexpression of RARG, and in bone marrow blasts from patients. Eventually, DC will test the activity of RARγ antagonist against the above AML cell lines, and against bone marrow blasts from patients.