The Influences of RARγ on the Behavior of Normal and Cancer Stem Cells – Geoffrey Brown

by Anneke_e | Oct 6, 2026 | Publication

Retinoic acid receptor γ (RARγ) is expressed mainly in stem and progenitor cells and helps control whether they maintain stemness or develop. This review by Geoffrey Brown draws on haematopoiesis, embryonic development, and the generation of induced pluripotent stem...

The Emerging Oncogenic Role of RARγ: From Stem Cell Regulation to a Potential Cancer Therapy – Geoffrey Brown

by Anneke_e | Oct 6, 2026 | Publication

Retinoic acid receptor γ (RARγ) is selectively expressed by normal stem cells and is needed to maintain them. This review argues that cancer cells, particularly cancer stem cells, have hijacked this role. RARγ is overexpressed in cholangiocarcinoma and in colorectal,...

Targeting Androgen, Thyroid Hormone, and Vitamin A and D Receptors to Treat Prostate Cancer – Hantusch et al.

by Anneke_e | Oct 6, 2026 | Publication

Androgen deprivation therapy is the core treatment for prostate cancer, but many patients progress to castration-resistant disease. This review examines four nuclear hormone receptors as additional targets, the androgen receptor (AR), thyroid hormone receptor β (TRβ),...

Structure and the Anticancer Activity of Vitamin D Receptor Agonists – Powała et al.

by Anneke_e | Oct 6, 2026 | Publication

Vitamin D is best known for its role in calcium homeostasis and bone health, but growing evidence indicates that its active form, calcitriol, also regulates cellular processes involved in cancer development, including proliferation, differentiation, apoptosis, and...

Small Particles, Big Problems: Polystyrene nanoparticles induce DNA damage, oxidative stress, migration, and mitogenic pathways predominantly in non-malignant lung cells – Ernhofer et al.

by Anneke_e | Oct 6, 2026 | Publication

In this study, Ernhofer et al. investigated the effects of polystyrene micro- and nanoplastics (PS-MNPs) on non-malignant and malignant lung cell models, as well as patient-derived lung organoids. While exposure to environmentally relevant concentrations did not...